Having dropped four in a row, the (6-6) will play the (9-3). The 49ers are big favorites (-10.5). The expected point total for the matchup is set at 47. Odds & Betting Lines49ers vs Seahawks Betting Information updated as of December 6, 2023, 10:33 AM ET.FavoriteSpreadFavorite Spread OddsUnderdog Spread OddsTotalOver Total OddsUnder Total Odds49ers-10.5-110-11047-110-110ADVERTISEMENT 49ers vs. Seahawks Prediction & PickPick ATS: San Francisco (-10.5)Pick OU: Under (47)Prediction: San Francisco 33 - Seattle 13How to Watch San Francisco vs. SeattleGame Date: Sunday, December 10, 2023Time: 4:05 PM ETVenue: Levi's StadiumLocation: Santa Clara, CaliforniaTV: Watch on FOX49ers vs. Seahawks Recent MatchupsOver their last five meetings, San Francisco has put up five wins versus Seattle.Seattle has been outscored by 69 points in its last five tilts against San Francisco.San Francisco Betting InfoSan Francisco has seven wins in 12 games versus the spread this season.The 49ers have covered the spread twice this season (2-1 ATS) when playing as at least 10.5-point favorites.San Francisco games this year have hit the over on six of 12 set point totals (50%).When playing as the moneyline favorite, the 49ers have won 75% of the time (9-3).San Francisco has played as a moneyline favorite of -600 or shorter in only two games this season, and it won both.The 49ers have an 85.7% chance to win this matchup, based on the implied probability of the moneyline.49ers StatsStatAverage (Total)RankPa s yards255.1 (3,061)7Rush yards136.8 (1,642)5Points scored29.3 (352)3Pa s yards against219.4 (2,633)14Rush yards against79.0 (948)1Points allowed15.8 (189)2San Francisco's Key PlayersOffenseChristian McCaffrey's rushing stat line this season includes 1,032 yards (first in the NFL) and 12 TDs. He's averaging 86.0 yards per game and 4.9 per attempt (seventh in the NFL).McCaffrey has 62 targets, 51 receptions, 429 receiving yards and five TDs in the pa sing game. has thrown for 3,185 yards (seventh in the NFL), 23 touchdowns (fourth in the NFL) and six interceptions this year. He averages 265.4 yards per game and 9.6 per attempt, while completing 70.2%.He has added 131 rushing yards (10.9 per game) and two touchdowns on the ground.In the pa sing attack, , has Derrick Rose Jersey racked up 927 receiving yards and six touchdowns after hauling in 50 balls on 72 targets. Per game, he's averaging 84.3 yards and 4.5 receptions through 11 games. has 38 receptions for 590 yards and three touchdowns. He's been targeted 53 times in the air attack, and averages 3.8 receptions and 59.0 yards through 10 games played.DefenseOver on the defensive side, has 99 tackles, 5.0 TFL, two sacks, and three interceptions in 2023. His tackle total leads the 49ers. has 8.0 sacks (first on the 49ers) in addition to his 10.0 TFL and 39 tackles. has put up 86 tackles, 5.0 TFL, and 1.5 sacks this year. He's second on the 49ers in tackles.So far this season, has 56 tackles, 1.0 TFL, and two interceptions.Seattle Betting InfoSeattle have compiled a 6-5-1 record against the spread this year.This year, Seattle games have hit the over six times.The Seahawks have entered the game as underdogs six times this season and won once.Seattle has not been a bigger underdog this season than the +440 moneyline set for this game.Bookmakers have implied with the moneyline set for this matchup that the Seahawks have a 18.5% chance to win.Seahawks StatsStatAverage (Total)RankPa s yards231.2 (2,774)14Rush yards93.8 (1,126)27Points scored22.0 (264)14Pa s yards against234.4 (2,813)23Rush yards against119.3 (1,431)21Points allowed24.2 (290)25Seattle's Key PlayersOffenseThrough 12 games played this year, has totaled 2,918 pa sing yards, with 15 touchdowns against nine interceptions and completing 64.4% of his attempts.He's added 92 yards on the ground (third on the Seahawks), while scoring one rushing touchdown. He's averaging 7.7 yards per game and 3.1 per attempt. has scored six rushing touchdowns, while totaling 613 rushing yards (4.1 per carry and 61.3 per game).Walker has also collected 173 receiving yards (17.3 per game) on 17 catches (1.7 per game). He's been targeted 23 times and has caught one touchdown pa s.In 11 games played this season, D.K. Metcalf has 49 catches (4.5 receptions per game on eight targets per game) for 812 yards and six receiving touchdowns. has 622 receiving yards and four touchdowns from 59 receptions after receiving 87 targets.DefenseSo far in 2023, Bobby Wagner has 2.5 sacks to go with 6.0 TFL and 127 tackles through 12 games.' stats include one interception as well as 96 tackles, 8.0 TFL, 4.5 sacks, and three pa ses defended. has 65 tackles, 4.0 TFL, three sacks, and one interception in the 2023 season. He is fifth on the Seahawks in tackles. has registered 1.0 TFL, 74 tackles, and one interception over 12 games.Herd Hierarchy: Packers, Texans jump in, Chiefs drop in Colin's Top 10 of Week 14 | The Herd Colin Cowherd reveals his Week 14 Herd Hierarchy, including the Green Bay Packers and Houston Texans leaping into the Top 10 and the Kansas City Chiefs dropping down. Deividas Sirvydis Jersey